Chemical substructures that enrich for biological activity
نویسندگان
چکیده
منابع مشابه
Chemical substructures that enrich for biological activity
MOTIVATION Certain chemical substructures are present in many drugs. This has led to the claim of 'privileged' substructures which are predisposed to bioactivity. Because bias in screening library construction could explain this phenomenon, the existence of privilege has been controversial. RESULTS Using diverse phenotypic assays, we defined bioactivity for multiple compound libraries. Many s...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btn479